中国科学报:电子烟对大脑发育有害


棉花糖味、水果味、焦糖布丁味……这不是在说真正的食物,而是如今电子烟的不同“口味”。

美国西雅图要和这些电子烟说“再见”,当地政府计划禁止电子烟。因为,这些口味诱人的电子烟,可能会使青少年吸电子烟的数量激增。这一禁令可以帮助正在走上“歧途”的青少年。

生产调味电子烟的公司现在必须遵守美国食品药品监督管理局(FDA)上个月发布的一项政策,禁止生产除烟草和薄荷醇以外的调味电子烟。

但是这些生产商仍然通过电子烟提供了一种非常吸引人上瘾的东西——尼古丁。而研究人员刚刚开始着手研究其对大脑发育的长期影响。

据《科学》杂志报道,在2月14日举行的美国科学促进会年会上,耶鲁大学神经科学家Marina Picciotto讲述了一些主要在动物身上得到的早期发现。她说,电子烟在过去10年中大受欢迎,“我们还不知道长期摄入电子烟的烟液或其中所含的尼古丁会带来什么后果”。但是现在已经初见端倪。

其中,有一点是从成年烟民身上得知的:尼古丁可以使人高度上瘾。有一些盒装的电子烟烟液中尼古丁含量与一包普通香烟相当。尼古丁“让你对原本喜欢的东西失去兴趣,而更喜欢它们。”Picciotto说。

对青少年来说,吸食电子烟可能与味觉有关,这可以使尼古丁变得更令人愉悦、更令人渴望。她说:“尼古丁增强了味道本身或其他原本效果较小的刺激物的反应效果。”对于青少年来说,这些刺激物可以是一段音乐或是一次愉快的体验,这使得尼古丁和“快乐”之间的联系更紧密。

到目前为止,Picciotto已经研究了尼古丁对小鼠大脑发育的长期影响。这项研究表明,暴露于尼古丁的成长期小鼠的脑细胞结构发生了变化,进而改变了信息在大脑中的传递方式。

这些暴露于尼古丁的小鼠对压力更敏感,并且会对一些不会使其他小鼠感到困扰的刺激做出反应。例如,那些脚受到微弱电击的暴露于尼古丁的小鼠会有反应,而未暴露其中的小鼠甚至没有意识到自己受了电击。

在对人进行的研究中,Picciotto也观察到了类似现象,比如出生前就暴露于尼古丁的儿童更容易对压力产生情绪上的过激反应。

Picciotto说,这一发现表明,处于尼古丁环境中的青少年,其大脑在发育过程中可能会发生结构性变化,从而对日后的行为产生负面影响。不过,她表示,还需要更多的研究进一步分析人们成年后的行为问题与尼古丁暴露之间的复杂关系。

Picciotto承认,对于成年吸烟者来说,改吸电子烟是有一定益处的。但是,哪些不吸烟的人,尤其是青少年,都不应该相信“吸电子烟时他们吸入的是无害蒸汽”。

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