iScience:电子烟的危害新发现,电子烟会破坏肠道屏障,触发体内炎症

2021年1月12日讯/生物谷BIOON/—电子烟(e-cigarette)被制造商吹捧为传统尼古丁香烟的“健康”替代品。在一项新的研究中,来自美国加州大学圣地亚哥分校的研究人员报道,电子烟中发现的化学物会破坏肠道屏障,并引发体内炎症,从而可能导致各种健康问题。相关研究结果于2021年1月5日在线发表在iScience期刊上,论文标题为“E-cigarettes compromise the gut barrier and trigger inflammation”。论文通讯作者为加州大学圣地亚哥分校的Soumita Das博士、Pradipta Ghosh博士和Laura E. Crotty-Alexander博士。
 
电子烟的危害
 
图片来自iScience, 2021, doi:10.1016/j.isci.2021.102035。
 
这些作者发现,长期使用不含尼古丁的电子烟会导致“肠漏(leaky gut)”,即微生物和其他分子从肠道中渗出,从而导致慢性炎症。这种炎症会导致各种疾病和症状,包括炎症性肠病、痴呆症、某些癌症、动脉硬化、肝纤维化、糖尿病和关节炎。
 
Ghosh说,“肠道内壁是一个神奇的实体。它由单层细胞组成,旨在将身体与数万亿个微生物隔离开来,保护我们的免疫系统,同时允许吸收必要的营养物。我们吃的或喝的任何东西,换句话说,我们的生活方式选择,都有能力影响我们的肠道微生物、肠道屏障和整体健康。如今,我们知道,吸电子烟也会对此产生负面影响。”
 
这些作者发现,作为所有电子烟液态蒸汽基础的两种化学物—丙二醇(propylene glycol)和植物甘油(vegetable glycerol)—是导致炎症的原因。
 
Ghosh说,“在吸电子烟时,当这两种物质被加热产生烟雾时,会形成众多的化学物,而这些化学物造成大量的伤害,目前还没有这方面的法律监管。电子烟的安全性一直是双方激烈争论的焦点。尼古丁的含量以及它的成瘾性,一直是那些反对其安全性的人的主要关注点,而电子烟的制造商在营销这些产品时,一直以电子烟缺乏香烟烟雾中的致癌物质将其作为‘健康的替代品’来宣传。实际上,我们更应该关注的是构成蒸汽液体的化学物,这是 因为它们是导致肠道炎症的原因。”
 
在这项新的研究中,这些作者使用了由患者细胞生成的人类肠道三维模型,并模拟了电子烟蒸汽进入肠道内壁时发生的情况。他们使用小鼠模型对这些研究结果进行了验证。
 
为了产生三维肠道类器官,这些作者从结肠镜检查中收集患者活检组织中的干细胞,并在体外进行培养。这些干细胞分化成组成肠道内壁的四种不同的细胞类型。然后,他们将这些类器官暴露在电子烟液体蒸汽中,模拟慢性吸烟者的电子烟使用频率。
 
他们注意到,上皮紧密连接标志物,即形成肠道第一道物理屏障的拉链状蛋白,开始破裂或松动,导致蒸汽中的病原体渗入周围的免疫系统,从而对刚好位于下面的保护性上皮细胞造成破坏。
 
这类细胞通过清除病原微生物,启动体内某些免疫反应,起到防御感染的作用。当暴露在电子烟液体中时,这些细胞很快就不堪重负,无法有效清除病原体,从而导致肠道炎症。
 
这项研究是HUMANOID卓越研究中心的一部分,该中心是位于加州大学圣地亚哥医学院的核心设施,由Ghosh和Das领导。该中心的科学家使用各种人类类器官和其他工具来模拟疾病和影响。
 
Das说,“这是第一项研究证实长期接触电子烟如何增加肠道对细菌感染的敏感性,从而导致慢性炎症和其他健康问题。鉴于肠道屏障在维持人体免疫平衡方面的重要性,这些研究结果为长期使用电子烟对我们健康的潜在长期有害影响提供了宝贵的见解。”
 
Ghosh说,如果消除了诱发因素—在这种情况下,指的是使用电子烟—对肠道内壁的损害可能会随着时间的推移而发生逆转,但是慢性炎症对心脏或大脑等其他器官的影响可能是不可逆的。Ghosh说,在未来,她和同事们计划研究电子烟的不同口味,以确定它们对肠道可能产生的影响。(生物谷 Bioon.com)
 
参考资料:
 
1.Aditi Sharma et al. E-cigarettes compromise the gut barrier and trigger inflammation. iScience, 2021, doi:10.1016/j.isci.2021.102035.
 
2.Study: e-cigarettes trigger inflammation in the gut
 
https://medicalxpress.com/news/2021-01-e-cigarettes-trigger-inflammation-gut.html
文章来源:电子烟,如若转载,请注明出处:http://www.hhdye.com/5559.html

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